Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition
نویسندگان
چکیده
منابع مشابه
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
Recent findings suggest that tau oligomers, which form before neurofibrillary tangles (NFTs), are the true neurotoxic tau entities in neurodegenerative tauopathies, including Alzheimer's disease (AD). Studies in animal models of tauopathy suggest that tau oligomers play a key role in eliciting behavioral and cognitive impairments. Here, we used a novel tau oligomer-specific monoclonal antibody ...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2014
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2013.10.019